Advanced Oxidative Stress Test (Whole Blood, Urine)

Address Chronic Disease at the Cellular Level

Precision Point Diagnostics revolutionizes oxidant stress testing with this innovative panel of biomarkers. The Advanced Oxidative Stress profile measures total glutathione, reduced glutathione, F2-isoprostane, and 8-OH-2deoxyguanosine from whole blood and urine specimens. Strong medical and scientific evidence points to oxidative stress as an underlying contributing factor to heart disease,1 neurodegenerative conditions,2-5 cancers,6 and toxicity.7,8 Now you have access to these cutting-edge markers to get an inside look at your patient’s oxidative/reductive (ox-redox) balance. With the results of this test, you can develop a targeted treatment protocol to correct rampant oxidative damage and foster a biochemical environment that makes healing possible.

There is a constant biochemical battle going on in the body to maintain oxidative or reductive balance. If your patient has too much oxidative stress, it could be a major underlying factor in their chronic illness. Most well-known for its role in aging, oxidative stress has been implicated in countless chronic diseases, not limited to Alzheimer’s disease, depression, diabetes, and Parkinson’s. When oxidative stress is rampant and antioxidant enzymes are overwhelmed, it means that mitochondria, DNA, proteins, lipid membranes, and cells are sustaining damage. Cells may die or malfunction. Dysfunctional proteins or DNA can trigger pathology. If rampant oxidative stress is not addressed, it is very difficult to halt or reverse the progression of chronic illness; and other treatments may not have their intended effects.

Conditions Associated with Oxidative Stress

  • Alzheimer’s disease9
  • Atherosclerosis5,10
  • Autism11
  • Autoimmune disorders12
  • Bipolar disorder13
  • Cancer10
  • Chronic inflammation5,10
  • Diabetes5,14
  • Gastrointestinal disorders15
  • Hormonal imbalance16,17
  • Major depressive disorder13,18
  • Neurodegenerative disorders5,10,19
  • Premature labor and stillbirth10
  • Rapid aging5
  • Schizophrenia13
  • Stroke5,19
  • Thyroid dysfunction20,21

Clinical Tools for Better Patient Outcomes

With results from the Advanced Oxidative Stress profile, you can design a treatment plan that will effectively bring your patient back into biochemical balance. We care about your patient outcomes. That’s why we provide comprehensive interpretive materials with specific treatment ideas commonly used by your fellow practitioners. When oxidative stress is curtailed, DNA, mitochondria, cells, tissues, and systems can function properly. The brain, heart, gut, and immune system can perform at peak capacity. This improves the overall picture of cellular health and reduces the risk of oxidative-stress-related health conditions.

References
1. Zhang ZJ. Systematic review on the association between F2-isoprostanes and cardiovascular disease. Ann Clin Biochem. 2013;50(Pt 2):108-114.
2. Montuschi P, Barnes PJ, Roberts LJ, 2nd. Isoprostanes: markers and mediators of oxidative stress. FASEB J. 2004;18(15):1791-1800.
3. Miller E, Morel A, Saso L, Saluk J. Isoprostanes and neuroprostanes as biomarkers of oxidative stress in neurodegenerative diseases. Oxidative medicine and cellular longevity. 2014;2014:572491.
4. Obeidat M, Miller S, Probert K, et al. GSTCD and INTS12 regulation and expression in the human lung. PloS one. 2013;8(9):e74630.
5. Uttara B, Singh AV, Zamboni P, Mahajan RT. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Current neuropharmacology. 2009;7(1):65-74.
6. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2′ -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. Journal of environmental science and health Part C, Environmental carcinogenesis & ecotoxicology reviews. 2009;27(2):120-139.
7. Lord RS, Bralley JA, eds. Laboratory Evaluations for Integrative and Functional Medicine. 2nd ed. Duluth, GA: Metametrix Institute; 2008.
8. Jayaprakash K. Mercury vapor inhalation and its effect on glutathione peroxidase in goldsmiths exposed occupationally. Toxicology and industrial health. 2009;25(7):463-465.
9. Pratico D. The neurobiology of isoprostanes and Alzheimer’s disease. Biochimica et biophysica acta. 2010;1801(8):930-933.
10. Roberts RA, Laskin DL, Smith CV, et al. Nitrative and oxidative stress in toxicology and disease. Toxicological sciences : an official journal of the Society of Toxicology. 2009;112(1):4-16.
11. Rose S, Melnyk S, Trusty TA, et al. Intracellular and extracellular redox status and free radical generation in primary immune cells from children with autism. Autism research and treatment. 2012;2012:986519.
12. Socha K, Kochanowicz J, Karpi Ska EB, et al. Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis. Nutrition journal. 2014;13(1):62.
13. Gawryluk JW, Wang JF, Andreazza AC, Shao L, Young LT. Decreased levels of glutathione, the major brain antioxidant, in post-mortem prefrontal cortex from patients with psychiatric disorders. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2011;14(1):123-130.
14. Piconi L, Quagliaro L, Ceriello A. Oxidative stress in diabetes. Clin Chem Lab Med. 2003;41(9):1144-1149.
15. Bhattacharyya A, Chattopadhyay R, Mitra S, Crowe SE. Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological reviews. 2014;94(2):329-354.
16. Aschbacher K, O’Donovan A, Wolkowitz OM, Dhabhar FS, Su Y, Epel E. Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity. Psychoneuroendocrinology. 2013;38(9):1698-1708.
17. Fortunato RS, Ferreira AC, Hecht F, Dupuy C, Carvalho DP. Sexual dimorphism and thyroid dysfunction: a matter of oxidative stress? The Journal of endocrinology. 2014;221(2):R31-40.
18. Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E. Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease. Journal of affective disorders. 2010;125(1-3):287-294.
19. Dasuri K, Zhang L, Keller JN. Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free radical biology & medicine. 2013;62:170-185.
20. Duthoit C, Estienne V, Giraud A, et al. Hydrogen peroxide-induced production of a 40 kDa immunoreactive thyroglobulin fragment in human thyroid cells: the onset of thyroid autoimmunity? The Biochemical journal. 2001;360(Pt 3):557-562.
21. El Hassani RA, Estienne V, Blanchin S, et al. Antigenicity and immunogenicity of the C-terminal peptide of human thyroglobulin. Peptides. 2004;25(6):1021-1029.