Gut Destruction: Food Allergy and Sensitivity and the Dance of Diamine Oxidase, Zonulin, LPS and Dysbiosis.

This lecture will review the interplay between complement activated food reactions, LPS Lipopolysaccharides, diamine oxidase the enzyme that degrades histamine, and Zonulin a regulator of tight junctions. Understanding the interplay of signaling gives clinical direction for treatment.

The gut is the major interface to the outside world. It is our first line of defense as well as where our first exposure happens.

It is where we decide if we are immune tolerant of the world or inflamed by the world. Recent research by Dr. Fassano demonstrates that the inflammatory contribution from the gut results in a host of systemic conditions, from neurologic to auto-immune but even contributing to diabetes and some cancers. He also affirms that movement away from a disease centered paradigm is possible by recognizing underlying processes that are occurring before pathology is evident. We will review highly evidenced biomarkers that map care.

The gut is our window to prevention and remission. By addressing the triggers of histamine, pathogens such as LPS and food sensitivities, as well as the body’s ability to handle the assault, through enzymes such as diamine oxidase that degrade histamine, we can halt inflammation and truly practice healthcare and promote wellness. Oral immunoglobulin therapy, strains of probiotics and other innovative therapies are specific for targeting the cause of Zonulin alterations and minimized Diamine Oxidase production. This lecture will enhance knowledge around the area of gut and its interplay between obesity, diabetes, and neuroendocrine dysfunction further widening our tools for treatment.



1) To understand the extensive influence the gut has on a myriad of pathologies not limited to the GI system.

2) We will review the systemic inflammatory pathways that are triggered from gut health.

3) To understand and be able to actualize the use of cutting-edge biomarkers such as Zonulin, Diamine oxidase, stool culture assessment and C3d/IgG food sensitivity assessment as they result to inflammatory process and pathology.

4) Review the research and evaluate the strength of the literature as it applies to biomarkers and successful natural modulation of these markers.

5) To learn more about food sensitivities and how we react

Major Learning Points:

1) The gut is the house of where the inflammatory process often begins. By understanding gut based tools, we have a profound ability to control inflammation in ways other than NSAIDs or steroids

2) Gut based inflammation plays a role in pathology that is not just in the gut as the inflammation that starts there affects tissue that is elsewhere in the body. Gut based inflammation can play a role in our CNS, cardiovascular system and endocrine system, not just our GI system.

3) The foods we eat, even those deemed healthy can be a major source of inflammation.

Attendees will receive $150 Credit towards a P88 Food Allergy/Sensitivity or Advanced Intestinal Barrier Assessment test.

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